Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
| one publication added to basket [238478] |
Chemistry of the nudibranch Aldisa andersoni: structure and biological activity of phorbazole metabolites
Nuzzo, G.; Ciavatta, M.L.; Kiss, R.; Mathieu, V.; Leclercqz, H.; Manzo, E.; Villani, G.; Mollo, E.; Lefranc, F.; D'Souza, L.; Gavagnin, M.; Cimino, G. (2012). Chemistry of the nudibranch Aldisa andersoni: structure and biological activity of phorbazole metabolites. Mar. Drugs 10(8): 1799-1811. http://dx.doi.org/10.3390/md10081799
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, meer
|   |
| Trefwoorden |
Aldisa andersoni Gosliner & Behrens, 2004 [WoRMS]; Nudibranchia [WoRMS]
Marien/Kust |
| Author keywords |
Aldisa andersoni; nudibranch mollusc; structural elucidation;feeding-deterrence; growth inhibitory assays |
| Auteurs | | Top |
- Nuzzo, G.
- Ciavatta, M.L.
- Kiss, R., meer
- Mathieu, V., meer
|
- Leclercqz, H.
- Manzo, E.
- Villani, G.
- Mollo, E.
|
- Lefranc, F.
- D'Souza, L.
- Gavagnin, M.
- Cimino, G.
|
| Abstract |
The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
