Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
| one publication added to basket [280772] |
Potential of Macrostomum lignano to recover from γ-ray irradiation
De Mulder, K.; Kuales, G.; Pfister, D.; Egger, B.; Seppi, T.; Eichberger, P.; Borgonie, G.; Ladurner, P. (2010). Potential of Macrostomum lignano to recover from γ-ray irradiation. Cell Tissue Res. 339(3): 527-542. dx.doi.org/10.1007/s00441-009-0915-6
In: Cell and Tissue Research. Springer: Berlin; Heidelberg. ISSN 0302-766x; e-ISSN 1432-0878, meer
|   |
| Trefwoorden |
Macrostomum lignano Ladurner, Schärer, Salvenmoser & Rieger, 2005 [WoRMS]; Planaria Müller, 1776 [WoRMS]
Marien/Kust |
| Author keywords |
Irradiation; Stem cells; Planaria; Flatworm; Macrostomum lignano(Platyhelminthes) |
| Auteurs | | Top |
- De Mulder, K., meer
- Kuales, G.
- Pfister, D.
- Egger, B.
|
- Seppi, T.
- Eichberger, P.
- Borgonie, G., meer
- Ladurner, P.
|
|
| Abstract |
Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
