Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
| one publication added to basket [285610] |
Marine invertebrate metabolites with anticancer activities: solutions to the "supply problem"
Gomes, N.G.M.; Dasari, R.; Chandra, S.; Kiss, R.; Kornienko, A. (2016). Marine invertebrate metabolites with anticancer activities: solutions to the "supply problem". Mar. Drugs 14(5): 98. https://dx.doi.org/10.3390/md14050098
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, meer
|   |
| Trefwoord |
|
| Author keywords |
eribulin; trabectedin; mycalamide A; spongistatin 1; stelletin A;monanchocidin A; phenylmethylene hydantoin; frondoside A; discodermolide |
| Auteurs | | Top |
- Gomes, N.G.M.
- Dasari, R.
- Chandra, S.
|
- Kiss, R., meer
- Kornienko, A.
|
|
| Abstract |
Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors' opinion should be pursued due to their most promising anticancer activities. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
