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Proteome map of the neural complex of the tunicate Ciona intestinalis, the closest living relative to vertebrates
Saxena, S.; Dupont, S.; Meghah, V.; Lakshmi, M.G.M.; Singh, S.K.; Swamy, C.V.B.; Idris, M.M. (2013). Proteome map of the neural complex of the tunicate Ciona intestinalis, the closest living relative to vertebrates. Proteomics (Weinh., Print) 13(5): 860-865. https://dx.doi.org/10.1002/pmic.201200148
In: Proteomics. Wiley-VCH: Weinheim. ISSN 1615-9853; e-ISSN 1615-9861, meer
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| Trefwoorden |
Exploitable Scientific Result
Marine Sciences
Marine Sciences > Marine Genomics
Scientific Community
Scientific Publication
Marien/Kust |
| Author keywords |
1DE; 2DE; Animal proteomics; High-throughput proteomics; LC-MS; MS;Proteome analysis |
| Project | Top | Auteurs |
- Association of European marine biological laboratories, meer
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| Auteurs | | Top |
- Saxena, S.
- Dupont, S.
- Meghah, V.
- Lakshmi, M.G.M.
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- Singh, S.K.
- Swamy, C.V.B.
- Idris, M.M.
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| Abstract |
Ciona intestinalis (the common sea squirt) is the closest living chordate relative to vertebrates with cosmopolitan presence worldwide. It has a relatively simple nervous system and development, making it a widely studied alternative model system in neuroscience and developmental biology. The use of Ciona as a model organism has increased significantly after the draft genome was published. In this study, we describe the first proteome map of the neural complex of C. intestinalis. A total of 544 proteins were identified based on 1DE and 2DE FTMS/ITMSMS analyses. Proteins were annotated against the Ciona database and analyzed to predict their molecular functions, roles in biological processes, and position in constructed network pathways. The identified Ciona neural complex proteome was found to map onto vertebrate nervous system pathways, including cytoskeleton remodeling neurofilaments, cell adhesion through the histamine receptor signaling pathway, γ-aminobutyric acid-A receptor life cycle neurophysiological process, glycolysis, and amino acid metabolism. The proteome map of the Ciona neural complex is the first step toward a better understanding of several important processes, including the evolution and regeneration capacity of the Ciona nervous system. |
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