Open WL Archief (OWA)

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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.

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one publication added to basket [2894]

Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and Artemia nauplii Verpraet, R.; Chair, M.; Léger, P.; Nelis, H.; Sorgeloos, P.; De Leenheer, A.P. (1992). Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and Artemia nauplii. Aquacult. Eng. 11: 133-139. https://dx.doi.org/10.1016/0144-8609(92)90015-P In: Aquacultural engineering. Elsevier: London. ISSN 0144-8609; e-ISSN 1873-5614, meer

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Beschikbaar in	Auteurs
VLIZ: Open Marine Archive 135408 [ download pdf ]

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Trefwoorden

Aquaculture systems Control > Disease control Drugs Food webs > Food chains Therapy Artemia Leach, 1819 [WoRMS] Brak water; Zoet water

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Auteurs		Top
Verpraet, R. Chair, M. Léger, P.	Nelis, H. Sorgeloos, P., meer De Leenheer, A.P.

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Abstract

The live food enrichment technique using emulsions for nutritional deficiencies in rotifers and Artemia was further investigated as a tool for transferring therapeutics through the food chain. Artemia nauplii and the rotifer Brachionus plicatilis were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimetoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as Artemia , was developed using High Performance Liquid Chromatography. When applying a 24h enrichment period, the accumulation of both drugs in Artemia nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116,mg/kg (protein basis) after 6h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in Artemia , suggesting different accumulation kinetics.

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