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Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
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| one publication added to basket [293874] |
Protection of peroxide-treated fish erythrocytes by coelenterazine and coelenteramine
Janssens, B.J.; Marchand-Brynaert, J.; Rees, J.F. (2002). Protection of peroxide-treated fish erythrocytes by coelenterazine and coelenteramine. Free Radical Research 36(9): 967-974. https://dx.doi.org/10.1080/107157621000006608
In: Free Radical Research. TAYLOR & FRANCIS LTD: Abingdon. ISSN 1071-5762; e-ISSN 1029-2470, meer
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coelenterazine; peroxide; erythrocytes; lipid peroxidation; glutathione;DNA damage |
| Auteurs | | Top |
- Janssens, B.J.
- Marchand-Brynaert, J.
- Rees, J.F., meer
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| Abstract |
European seabass (Dicentrarchus labrax) erythrocytes treated with tert-butyl hydroperoxide (t-BHP) showed decreasing levels of reduced glutathione, increased lipid peroxidation and DNA damage, and ultimately underwent haemolysis. The addition of the marine luciferin coelenterazine (CLZn) markedly delayed the onset of the haemolytic process induced by t-BHP as well as lipid peroxidation and glutathione oxidation. CLZn also protected the red blood cells' DNA against t-BHP-triggered damage. CLZn's oxidation product coelenteramine (CLM) also delayed the lysis of the cells as well as the occurrence of oxidative stress indicators but it did not offer protection against DNA damage. Both compounds proved more efficient than the vitamin E analogue Trolox C(R) at similar doses. These results demonstrate the ability of CLZn and CLM to protect fish cells against oxidative stress, providing further support to the evolutionary model suggesting that CLZn's first physiological role was that of an antioxidant in fish thriving in surface layers of the ocean, later evolving into its light-emitting function in deep-sea species. |
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