Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
one publication added to basket [359783] |
Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins
Davidson, P.L.; Guo, H.; Swart, J.S.; Massri, A.J.; Edgar, A.; Wang, L.; Berrio, A.; Devens, H.R.; Koop, D.; Cisternas, P.; Zhang, H.; Zhang, Y.; Byrne, M.; Fan, G.; Wray, G.A. (2022). Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins. Nature Ecology & Evolution 6(12): 1907-1920. https://dx.doi.org/10.1038/s41559-022-01906-9
In: Nature Ecology & Evolution. Springer Nature. ISSN 2397-334X, meer
| |
Trefwoorden |
Heliocidaris L. Agassiz & Desor, 1846 [WoRMS] Marien/Kust |
Auteurs | | Top |
- Davidson, P.L.
- Guo, H.
- Swart, J.S.
- Massri, A.J.
- Edgar, A.
|
- Wang, L.
- Berrio, A.
- Devens, H.R.
- Koop, D.
- Cisternas, P.
|
- Zhang, H., meer
- Zhang, Y.
- Byrne, M.
- Fan, G.
- Wray, G.A.
|
Abstract |
Changes in developmental gene regulatory networks (dGRNs) underlie much of the diversity of life, but the evolutionary mechanisms that operate on regulatory interactions remain poorly understood. Closely related species with extreme phenotypic divergence provide a valuable window into the genetic and molecular basis for changes in dGRNs and their relationship to adaptive changes in organismal traits. Here we analyse genomes, epigenomes and transcriptomes during early development in two Heliocidaris sea urchin species that exhibit highly divergent life histories and in an outgroup species. Positive selection and chromatin accessibility modifications within putative regulatory elements are enriched on the branch leading to the derived life history, particularly near dGRN genes. Single-cell transcriptomes reveal a dramatic delay in cell fate specification in the derived state, which also has far fewer open chromatin regions, especially near conserved cell fate specification genes. Experimentally perturbing key transcription factors reveals profound evolutionary changes to early embryonic patterning events, disrupting regulatory interactions previously conserved for ~225 million years. These results demonstrate that natural selection can rapidly reshape developmental gene expression on a broad scale when selective regimes abruptly change. More broadly, even highly conserved dGRNs and patterning mechanisms in the early embryo remain evolvable under appropriate ecological circumstances. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.