Over het archief
Het OWA, het open archief van het Waterbouwkundig Laboratorium heeft tot doel alle vrij toegankelijke onderzoeksresultaten van dit instituut in digitale vorm aan te bieden. Op die manier wil het de zichtbaarheid, verspreiding en gebruik van deze onderzoeksresultaten, alsook de wetenschappelijke communicatie maximaal bevorderen.
Dit archief wordt uitgebouwd en beheerd volgens de principes van de Open Access Movement, en het daaruit ontstane Open Archives Initiative.
Basisinformatie over ‘Open Access to scholarly information'.
Comparative acute toxicity of the first 50 Multicenter Evaluation of In Vitro Cytotoxicity chemicals to aquatic non-vertebrates
Calleja, M.C.; Persoone, G.; Geladi, P. (1994). Comparative acute toxicity of the first 50 Multicenter Evaluation of In Vitro Cytotoxicity chemicals to aquatic non-vertebrates. Arch. Environ. Contam. Toxicol. 26: 69-78. https://dx.doi.org/10.1007/BF00212796
In: Archives of Environmental Contamination and Toxicology. Springer: New York. ISSN 0090-4341; e-ISSN 1432-0703, meer
|  |
| Trefwoorden |
Materials > Hazardous materials > Biological poisons
Organisms
Organisms
Organisms
Seeds
Tests > Bioassays
|
| Auteurs | | Top |
- Calleja, M.C.
- Persoone, G., meer
- Geladi, P.
|
|
|
| Abstract |
The acute toxicity data of the first 50 chemicals of the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme is compared for three ''cyst-based toxicity tests'' (Artoxkit M with Artemia salina, Streptoxkit F with Streptocephalus proboscideus, and Rotoxkit F with Brachionus calyciflorus), and two other tests (the Daphnia magna and the Photobacterium phosphoreum Microtox(TM) tests) commonly used in ecotoxicology. The difference in sensitivity for the 50 chemicals was as high as 19 orders of magnitude (on a molecular weight basis) between the most and least sensitive species. Generally, a similar toxicity ranking of the 5 test species was found for most of the chemicals and the interspecies correlations were high. Results from principal Component Analysis (PCA) and cluster analysis indicated that the groupings are not related to a clear and defined chemical structure. However, the loading plot of the first two principal components may aid in selecting the minimum number and type of tests that have to be included in a battery which encompasses a broad spectrum of toxicity levels. Consequently, this study supports the use of a selected battery of tests to evaluate ecotoxicity and suggests its possible importance for screening of biologically-active compounds from natural sources. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
