Zoeken
Zoeken kan via de modus 'eenvoudig zoeken' (één veld) of uitgebreid via 'geavanceerd zoeken' (meerdere velden). Zo kan je bv. zoeken op een combinatie van een auteursnaam (auteur), een jaartal (jaar) en een documenttype.
Boekenmand
Nuttige resultaten kan je aanvinken en toevoegen aan een mandje. De inhoud hiervan kan je exporteren of afdrukken (naar bv. PDF).
RSS
Op de hoogte blijven van nieuw toegevoegde publicaties binnen uw interessegebied? Dit kan door een RSS-feed (?) te maken van jouw zoekopdracht.
nieuwe zoekopdracht
| one publication added to basket [238271] |
Detecting genome-wide gene transcription profiles associated with high pollution burden in the critically endangered European eel
Pujolar, J.M.; Milan, M.; Marino, I.A.M.; Capoccioni, F.; Ciccotti, E.; Belpaire, C.; Covaci, A.; Malarvannan, G.; Patarnello, T.; Bargelloni, L.; Zane, L.; Maes, G.E. (2013). Detecting genome-wide gene transcription profiles associated with high pollution burden in the critically endangered European eel. Aquat. Toxicol. 132-133: 157-164. dx.doi.org/10.1016/j.aquatox.2013.02.012
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514
|  |
| Trefwoord |
Anguilla anguilla (Linnaeus, 1758) [WoRMS]
|
| Author keywords |
Anguilla anguilla; European eel; Microarrays; Pollution; Transcriptomics |
| Auteurs | | Top |
- Pujolar, J.M.
- Milan, M.
- Marino, I.A.M.
- Capoccioni, F.
|
- Ciccotti, E.
- Belpaire, C.
- Covaci, A.
- Malarvannan, G.
|
- Patarnello, T.
- Bargelloni, L.
- Zane, L.
- Maes, G.E.
|
| Abstract |
The European eel illustrates an example of a critically endangered fish species strongly affected by human stressors throughout its life cycle, in which pollution is considered to be one of the factors responsible for the decline of the stock. The objective of our study was to better understand the transcriptional response of European eels chronically exposed to pollutants in their natural environment. A total of 42 pre-migrating (silver) female eels from lowly, highly and extremely polluted environments in Belgium and, for comparative purposes, a lowly polluted habitat in Italy were measured for polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and brominated flame retardants (BERs). Multipollutant level of bioaccumulation was linked to their genome-wide gene transcription using an eel-specific array of 14,913 annotated cDNAs. Shared responses to pollutant exposure were observed when comparing the highly polluted site in Belgium with the relatively clean sites in Belgium and Italy. First, an altered pattern of transcription of genes was associated with detoxification, with a novel European eel CYP3A gene and gluthatione S-transferase transcriptionally up-regulated. Second, an altered pattern of transcription of genes associated with the oxidative phosphorylation pathway, with the following genes involved in the generation of ATP being transcriptionally down-regulated in individuals from the highly polluted site: NADH dehydrogenase, succinate dehydrogenase, ubiquinol-cytochrome c reductase, cytochrome c oxidase and ATP synthase. Although we did not measure metabolism directly, seeing that the transcription level of many genes encoding enzymes involved in the mitochondrial respiratory chain and oxidative phosphorylation were down-regulated in the highly polluted site suggests that pollutants may have a significant effect on energy metabolism in these fish. |
IMIS is ontwikkeld en wordt gehost door het VLIZ.
